Generic Name: lamivudine (la MIV ue deen)
Brand Name: Epivir, Epivir HBV
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What is lamivudine?
Lamivudine is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B virus from multiplying in your body.
Epivir is for treating HIV in adults and children at least 3 months old. HIV is the virus that can cause acquired immunodeficiency syndrome (AIDS). Epivir is not a cure for HIV or AIDS.
Epivir-HBV is for treating hepatitis B in adults and children at least 2 years old. Epivir-HBV should not be used in people who are infected with both hepatitis B and HIV.
Lamivudine may also be used for purposes not listed in this medication guide.
You should not take Epivir-HBV (for treating hepatitis B) if you also take other medicine that contains lamivudine or emtricitabine.
Lamivudine can cause severe or life-threatening effects on your liver or pancreas. Call your doctor at once if you have: severe pain in your upper stomach spreading to your back, nausea, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes).
If you’ve ever had hepatitis B, it may become active or get worse after you stop using lamivudine. You may need frequent liver function tests for several months.
The hepatitis B virus may become resistant to treatment while you are taking Epivir-HBV. Resistant hepatitis B can lead to worsening liver disease or death. Tell your doctor if you have new hepatitis symptoms.
Before taking this medicine
You should not take lamivudine if you are allergic to it.
You should not take Epivir-HBV (for treating hepatitis B) if you also take other medicine that contains lamivudine or emtricitabine, which includes Atripla, Biktarvy, Cimduo, Combivir, Complera, Descovy, Emtriva, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, and Truvada.
Tell your doctor if you have ever had:
liver disease (especially hepatitis B or C, or a liver transplant);
kidney disease; or
diabetes (liquid lamivudine contains 3 to 4 grams of sucrose per dose).
You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. This may be more likely if you have other medical conditions, if you’ve taken HIV medication for a long time, or if you are a woman. Ask your doctor about your risk.
Tell your doctor if you are pregnant, and use your medications properly to control your infection. HIV can be passed to your baby if the virus is not controlled during pregnancy. Your name may be listed on a registry to track any effects of antiviral medicine on the baby.
You should not breastfeed while you are using lamivudine to treat hepatitis B. Women with HIV or AIDS should not breast feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
How should I take lamivudine?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. You should not take Epivir (for treating HIV) together with Epivir-HBV (for treating hepatitis B).
You may take lamivudine with or without food.
Lamivudine doses are based on weight in children. Your child’s dose needs may change if the child gains or loses weight. Children who weigh more than 30 pounds (14 kilograms) should use the tablet form of lamivudine if possible. Lamivudine liquid may not be as effective.
You may need to break an Epivir tablet in half when giving lamivudine to a child for HIV. Call your doctor if the child has any trouble swallowing the tablet.
Measure liquid medicine carefully. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).
The Epivir brand contains a higher dose of lamivudine than Epivir-HBV brand. Epivir is for treating HIV and Epivir-HBV is for treating hepatitis B. Each time you get a refill of this medication, be sure you have received the correct brand to treat your condition.
You will need frequent medical tests, including frequent HIV testing. If you become infected with HIV while you are taking lamivudine to treat hepatitis B, the HIV could become resistant to antiviral medicines if not treated right away.
The hepatitis B virus can mutate while you are taking Epivir-HBV and may become resistant to treatment. Resistant hepatitis B can lead to worsening liver disease or death. Tell your doctor if you have new or worsening hepatitis symptoms.
Use all HIV medications as directed and read all medication guides you receive. Do not change your dose or dosing schedule without your doctor’s advice. Every person with HIV should remain under the care of a doctor.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
If you’ve ever had hepatitis B, this virus may become active or get worse in the months after you stop using lamivudine. You may need frequent liver function tests while using this medicine and for several months after your last dose.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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